GLP1 10mg
$129.00
GLP1 is semaglutide, a synthetic 31 amino acid GLP-1 analog with a C18 diacid side chain, supplied lyophilized as a reference standard for laboratory research.
- 31 residue backbone with Aib at position 8 and a fatty diacid side chain at Lys26
- Lot matched certificate of analysis with every order
- Research use only. Not for human or veterinary use
50 in stock
- Research use only Not for human or veterinary use
- COA with every lot Lot number on the vial matches the certificate
- Third party tested RP-HPLC with LC-MS identity, 98%+ purity spec
- Restricted sale 18+ researchers, US orders only
What is GLP1?
GLP1 is semaglutide, a synthetic analog of glucagon-like peptide-1, built on a 31 amino acid backbone derived from the GLP-1 (7-37) sequence. Two features distinguish it from the native sequence: alpha-aminoisobutyric acid replaces alanine at position 8, and a C18 fatty diacid chain is attached at lysine 26 through a gamma-glutamyl and bis-ethylene glycol spacer. It is supplied as a lyophilized powder for laboratory research use as a reference standard.
GLP1 (semaglutide) structure and modifications
The molecular weight is approximately 4113.58 Da. The Aib substitution at position 8 removes the dipeptidyl peptidase-4 cleavage site that limits the stability of the native sequence, and the acylated side chain at Lys26 drives albumin binding, which is the property that dominates its behaviour in binding assays. Both modifications are visible analytically: the side chain shifts retention substantially under reversed phase conditions and gives a defined mass increment under LC-MS.
Where this material appears in the literature
Semaglutide appears in receptor pharmacology, in peptide chemistry literature on acylation strategies, and widely in bioanalytical method development. Iron Rack Labs supplies the material as a laboratory reference standard and makes no claim about what it does in any living subject.
Related material in the catalogue
GLP1 is held under reference standards, alongside GLP2 (tirzepatide) and GLP3 (retatrutide), the other GLP-class reference sequences in the catalogue.
Analysis and certification
Every lot is analyzed by an independent laboratory before release, using RP-HPLC for purity and LC-MS for identity confirmation. The certificate of analysis is published against the lot number rather than against the product page, so the document you read is the document for the vial you receive. The lot number printed on the vial label is the link between the two.
Purity specification
Lots are released against a ≥98% purity specification, determined by RP-HPLC peak area. A specification is a release threshold, not a description of every lot. The measured figure for the lot you receive is stated on its certificate of analysis and may sit above the specification.
Where a measured figure and the specification differ, the certificate is the record that applies to your material. Analytical figures relate to the lot they are published against and carry no implication of suitability for any purpose beyond laboratory research.
Research use only
Iron Rack Labs supplies this material as a reference standard for laboratory research. It is not supplied for any use in humans or animals, it is not a drug, dietary supplement, food or cosmetic, and nothing on this page describes or implies any such use. Sale is restricted to persons aged 18 or over who are qualified researchers or who purchase on behalf of a research institution, laboratory or business.
| Compound | Semaglutide |
|---|---|
| Also known as | GLP-1 analog, NN9535 |
| Class | Synthetic acylated GLP-1 analog |
| Amino acids | 31 |
| Sequence | GLP-1 (7-37) backbone with Aib8 and Arg34 substitutions and a C18 diacid chain at Lys26 via gamma-Glu and two OEG spacers |
| Molecular weight | Approximately 4113.58 Da |
| CAS number | 910463-68-2 |
| Appearance | White to off white lyophilized powder |
| Purity specification | ≥98% |
| Purity method | RP-HPLC |
| Identity method | LC-MS |
| Solubility | Soluble in sterile water and aqueous buffers for analytical preparation; solubility is pH dependent and lowest near the isoelectric point |
| Labeled quantity | 10mg per vial |
Characterization. Values above describe the compound as supplied. The figures for the lot you receive, including measured purity, are stated on its certificate of analysis.
How this material is tested
Two separate analyses are carried out on every lot before release, and both appear on the certificate.
- RP-HPLC, for purity. Reversed phase high performance liquid chromatography separates the material by hydrophobicity. The main peak is integrated against total peak area, and that ratio is the purity figure reported on the certificate.
- LC-MS, for identity. Liquid chromatography coupled to mass spectrometry confirms that the mass of the main peak matches the expected mass for the compound, which is what distinguishes the correct sequence from a closely related one.
A complete certificate carries the compound name, the lot number, the test date, the method, the measured purity and the name of the laboratory. If any of those is missing, or the lot number on the vial does not match the certificate, contact us before using the material.
Storing Semaglutide
Lyophilized material is shipped cold and should be moved into freezer storage on arrival. Store the sealed vial dry at −20°C or below, protected from light and moisture. Returned promptly to those conditions, the dry solid is the most stable form this material takes.
Preparing stock solutions
Prepare stock solutions in sterile water or an appropriate aqueous buffer at a concentration suited to your assay, expressed in mg/mL. Allow the vial to reach room temperature before opening, add solvent down the vial wall rather than directly onto the solid, and let the material dissolve without vigorous agitation. Acylated peptides are surface active and can adsorb to labware. Prepare stocks at a workable concentration, mix gently rather than vortexing hard, and avoid foaming.
Solutions are less stable than the lyophilized solid. Prepare close to the point of use, hold at 2 to 8°C for short periods only, and aliquot before freezing so that repeated freeze and thaw cycles are avoided.
On arrival
Check that the vial is intact and sealed, that the compound name and labeled quantity match your order, and that the lot number on the label matches the certificate published for it. If anything does not match, or the packaging has clearly failed in transit, contact us before using the material. Problems visible on arrival should be reported within 7 days so that a carrier claim remains possible.
Handling and disposal
Assess the hazards of this material before handling it and use appropriate controls and protective equipment. It has not been characterized toxicologically and should be treated as potentially hazardous. Anyone handling it should be trained for the work.
Dispose of unused material, vials and packaging lawfully and in line with your institution's waste procedures.
Record keeping
Record the lot number in your notes at the point of first use, alongside the date the vial was opened and the concentration of any stock prepared. Certificates are published against the lot number rather than the product, so the lot number is the only reliable link between your results and the analytical data for the material that produced them. If a question arises about a result months later, that link is what keeps the work auditable.
What purity specification does this material meet?
Lots are released against a ≥98% specification, determined by RP-HPLC, with identity confirmed by LC-MS. The measured figure for the lot you receive is stated on its certificate of analysis.
How do I match my vial to its certificate?
By lot number. The vial label carries the compound, the labeled quantity and the lot number, and the certificate is published against that same lot number. Record it in your notes at first use.
Can I see a certificate before ordering?
Yes. Every published certificate is in the COA library, and you can contact us to confirm which lot is currently in stock and to receive its certificate directly.
How is it shipped?
Cold, in temperature stable packaging, on a tracked domestic service from our US facility. Outer packaging is plain and does not carry compound names.
Who is eligible to order?
Sale is restricted to persons aged 18 or over who are qualified researchers, or who purchase on behalf of a research institution, laboratory or business. This website is not an offer to supply to the general public.
Is this material suitable for use in humans or animals?
No. It is supplied as a reference standard for laboratory research only. It is not a drug, dietary supplement, food or cosmetic, and it is not supplied for any use in humans or animals.
Need a compound that is not listed?
Tell the lab which material and what quantity you need and we will confirm stock, lot availability and lead time. Research use only.
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